endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2024-5-3-04endofocus-110Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWЗаместительная терапия гипотиреоза в отдельных группах пациентовReplacement therapy for hypothyroidism in special groups of patientshttps://orcid.org/0000-0003-1500-1586МоргуноваТ. Б.MorgunovaT. B.

Моргунова Татьяна Борисовна – к.м.н., доцент кафедры эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

г. Москва

Tatyana B. Morgunova – Candidate of sciences (PhD) in medicine, Associate Professor, Department of Endocrinology No.1

Moscow

tanmorgun@mail.ruhttps://orcid.org/0000-0003-0069-1692РыжковаЕ. Г.RyzhkovaE. G.

Рыжкова Екатерина Геннадьевна – аспирант кафедры эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

г. Москва

Ekaterina G. Ryzhkova – Posrgraduate student, Department of Endocrinology No.1

Moscow

e.g.ryzhkova@bk.ruhttps://orcid.org/0000-0001-8882-022XСтроковаМ. И.StrokovaM. I.

Строкова Марина Игоревна – аспирант кафедры эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

г. Москва

Marina I. Strokova – resident, Department of Endocrinology No.1

Moscow

strokova.m.i@gmail.comhttps://orcid.org/0000-0002-3026-6315ФадеевВ. В.FadeyevV. V.

Фадеев Валентин Викторович – д.м.н., профессор, член-корр. РАН, заведующий кафедрой эндокринологии №1 Института клинической медицины им. Н.В. Склифосовского

г. Москва

Valentin V. Fadeyev – Doctor of medical sciences, Professor, Сorresponding member of the RAS, Head, Department of Endocrinology No.1

Moscow

walfad@mail.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииI.M. Sechenov First Moscow State Medical University (Sechenov University)202407112024533035Copyright © Моргунова Т.Б., Рыжкова Е.Г., Строкова М.И., Фадеев В.В., 20242024Моргунова Т.Б., Рыжкова Е.Г., Строкова М.И., Фадеев В.В.Morgunova T.B., Ryzhkova E.G., Strokova M.I., Fadeyev V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/110

Первичный гипотиреоз является одним из наиболее распространенных эндокринных заболеваний. При развитии манифестного гипотиреоза показано назначение заместительной терапии левотироксином. Современные таблетированные препараты левотироксина обеспечивают удобство приема и простоту подбора дозы препарата. Вместе с тем достаточно большое число пациентов, длительно получающих препараты левотироксина, находятся в состоянии декомпенсации. Причинами ее могут служить низкая приверженность пациента лечению, прием лекарственных препаратов или патология желудочно-кишечного тракта, которые могут влиять на биодоступность левотироксина. Данный обзор посвящен обсуждению проблемы декомпенсации гипотиреоза и влиянию приверженности лечению на эффективность заместительной терапии.

Primary hypothyroidism is one of the most common endocrine diseases. The replacement therapy with levothyroxine is indicated to all patients with overt hypothyroidism. Modern tablet preparations of levothyroxine provide easy administration, simplicity of selection of the drug dose. At the same time, a fairly large number of patients who have been receiving levothyroxine preparations for a long time are in a state of decompensation. The reasons for decompensation may be low patient adherence, receiving of drugs or gastrointestinal pathology, which can affect the bio-availability of levothyroxine. This review is devoted to the discussion of the problem of decompensation of hypothyroidism and the influence of patient’s adherence on the efficacy of replacement therapy.

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The authors declare that there are no conflicts of interest present.