endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2025-6-2-08endofocus-153Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWИсходы, сообщаемые пациентами, при деинтенсификации сложных режимов инсулинотерапии сахарного диабета 2 типаOutcomes reported by patients during de-intensification of complex insulin therapy regimens for type 2 diabetes mellitushttps://orcid.org/0000-0002-9296-4346ЯновскаяЕ. А.YanovskayaE. A.

Яновская Елена Александровна – к.м.н., ассистент кафедры терапии им. профессора Е.Н. Дормидонтова

г. Ярославль

Elena A. Yanovskaya – C. Sci. (Med.), Assistant at the Department of therapy named after professor E.N. Dormidontov

Yaroslavl

lenayan2005@rambler.ruЯновскаяМ. Е.YanovskayaM. E.

Яновская Мария Ефимовна – к.м.н., заведующая эндокринологическим отделением

г. Ярославль

Mariya E. Yanovskaya – C. Sci. (Med.), head of the Department of endocrinology, Regional Clinical Hospital

Yaroslavl

ФГБУ ВО «Ярославский государственный медицинский университет» Минздрава РоссииYaroslavl State Medical University20252506202562Кардиоэндокринология64–67Copyright © Яновская Е.А., Яновская М.Е., 20252025Яновская Е.А., Яновская М.Е.Yanovskaya E.A., Yanovskaya M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/153

В современной диабетологии растет интерес к исходам, сообщаемым пациентами (ИСП), как важному показателю, влияющему на эффективность терапии. В представленном обзоре анализируется влияние деинтенсификации сложных режимов инсулинотерапии с использованием препарата иГларЛикси (комбинации инсулина гларгин 100 Ед/мл и ликсисенатида) на качество жизни и удовлетворенность лечением пациентов с сахарным диабетом 2 типа (СД2). Рассмотрены результаты ключевых исследований (SoliSwitch, IDEAL, SIMPLIFY Japan), демонстрирующих значительное улучшение показателей ИСП при переходе с многократных инъекций инсулина или готовых смесей на однократное введение иГларЛикси. Наиболее выраженные улучшения отмечены в доменах «бремя лечения» и «управление диабетом». С учетом влияния психосоциальных факторов на восприятие терапии и приверженность лечению деинтенсификация инсулинотерапии может быть особенно значима для пациентов, испытывающих стигматизацию и диабетический дистресс. Результаты обзора подтверждают, что перевод пациентов на иГларЛикси является эффективной стратегией деинтенсификации, улучшающей как гликемический контроль, так и качество жизни при СД2.

In modern diabetology, there is a growing interest in patient-reported outcomes (COI) as an important indicator influencing the effectiveness of therapy. This review analyzes the effect of de-intensification of complex insulin therapy regimens using the drug Iglarlixi (a combination of insulin glargine 100 U/ml and lixisenatide) on the quality of life and satisfaction with treatment in patients with type 2 diabetes mellitus (T2DM). The results of key studies (SoliSwitch, IDEAL, SIMPLIFY Japan) are reviewed, demonstrating a significant improvement in COI indicators when switching from multiple injections of insulin or ready-made mixtures to a single injection of Iglarlixi. The most pronounced improvements were noted in the domains “Burden of treatment” and “Diabetes management”. Given the influence of psychosocial factors on the perception of therapy and treatment adherence, de-intensification of insulin therapy may be especially important for patients experiencing stigmatization and diabetic distress. The review results confirm that switching to Iglarlixi is an effective de-intensification strategy that improves both glycemic control and quality of life in patients with T2DM.

сахарный диабет 2 типадеинтенсификация терапииисходысообщаемые пациентамииГларЛиксикачество жизниудовлетворенность лечениеминсулинотерапияфиксированная комбинацияагонисты рецепторов глюкагоноподобного пептида-1приверженность лечениюtype 2 diabetes mellitusintensification of therapypatient-reported outcomesIglarlixiquality of lifesatisfaction with treatmentinsulin therapyfixed combinationGLP-1 receptor agoniststreatment adherenceReferencesHolmes-Truscott E, Browne JL, Ventura AD et al. Diabetes stigma is associated with negative treatment appraisals among adults with insulin-treated type 2 diabetes: Results from the second Diabetes MILES – Australia (MILES-2) survey. Diabetic Med. 2018; 35(5): 658–62. doi: 10.1111/dme.13598.Holmes-Truscott E, Browne JL, Ventura AD et al. Diabetes stigma is associated with negative treatment appraisals among adults with insulin-treated type 2 diabetes: Results from the second Diabetes MILES – Australia (MILES-2) survey. 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The authors declare that there are no conflicts of interest present.