endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2025-6-3-05endofocus-160Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWСахарный диабет и печень: неочевидные аспектыDiabetes mellitus and liver: Non-obvious aspectshttps://orcid.org/0000-0002-5041-3466БуеверовА. О.BueverovA. O.

Буеверов Алексей Олегович – д.м.н., профессор, ведущий научный сотрудник отделения гепатологии, профессор курса «Гепатология»

г. Москва

Alexey O. Bueverov – D. Sci (Med), Professor, Leading Researcher at the Department of Hepatology, Professor of the course “Hepatology”

Moscow

bcl72@yandex.ruhttps://orcid.org/0000-0002-0700-9775БуевероваЕ. Л.BueverovaE. L.

Буеверова Елена Леонидовна – к.м.н., доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и гепатологии

г. Москва

Elena L. Bueverova – C. Sci (Med), Associate Professor of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Hepatology 

Moscow

bueverova_e_l@staff.sehenov.ruГБУ МЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»M.F. Vladimirsky Moscow Regional Research Clinical InstituteФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)I.M. Sechenov First Moscow State Medical University (Sechenov University)202513112025634146Copyright © Буеверов А.О., Буеверова Е.Л., 20252025Буеверов А.О., Буеверова Е.Л.Bueverov A.O., Bueverova E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/160

Поражение печени может наблюдаться при сахарном диабете не только 1 типа (СД1), но и 2 типа (СД2). Можно с уверенностью утверждать об обоюдной патогенетической связи СД2 и метаболически ассоциированной жировой болезни печени (МАЖБП). МАЖБП выступает в качестве независимого патогенетического фактора прогрессирования сердечно-сосудистых, почечных, онкологических заболеваний. У больных СД1 описано три варианта печеночной патологии – МАЖБП, гликогеновая гепатопатия и диабетический гепатосклероз, при этом два последних, возможно, являются патогномоничными для этого типа диабета. Представление практикующих врачей о вариантах поражения печени при диабете позволяет эффективно контролировать факторы риска и избегать назначения неоправданных исследований и неэффективных лекарственных препаратов.

Liver damage can occur in diabetes mellitus, not only type 1 (T1DM), but also type 2 (T2DM). It can be confidently stated that there is a mutual pathogenetic relationship between T2DM and metabolic-associated fatty liver disease (MAFLD). MAFLD acts as an independent pathogenetic factor in the progression of cardiovascular, renal, and oncological diseases. Three variants of liver pathology have been described in patients with T1DM: MAFLD, glycogen hepatopathy, and diabetic hepatosclerosis, while the latter two may be pathognomonic for this type of diabetes. The representation of practitioners about the options for liver damage in diabetes makes it possible to effectively control risk factors and avoid prescribing unjustified studies and ineffective medications.

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The authors declare that there are no conflicts of interest present.