endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2025-6-3-07endofocus-179Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWЭффекты препаратов инкретинового ряда в отношении контроля гликемии и массы телаEffects of incretin drugs on glycemic control and body weighthttps://orcid.org/0000-0002-9430-0391ЛевицкаяА. Н.LevitskayaA. N.

Левицкая Анастасия Николаевна – ассистент кафедры эндокринологии 

г. Москва

Anastasiya N. Levitskaya – assistant at the Department of endocrinology of the Faculty of general medicine

Moscow

levitskaya.anastasiya@internet.ruhttps://orcid.org/0000-0001-6385-540XДемидоваТ. Ю.DemidovaT. Yu.

Демидова Татьяна Юльевна – д.м.н., профессор, заведующая кафедрой эндокринологии

Scopus Author ID: 7003771623

г. Москва

Yu. Demidova – D. Sci. (Med.), Prof., Head of the Department of Endocrinology, Institute of Clinical Medicine

Scopus Author ID: 7003771623

Moscow

t.y.demidova@gmail.comhttps://orcid.org/0000-0002-3656-0312ЛобановаК. Г.LobanovaK. G.

Лобанова Кристина Геннадьевна – к.м.н., ассистент кафедры эндокринологии ИКМ 

г. Москва

Kristina G. Lobanova – C. Sci. (Med.), assistant at the Department of Endocrinology, Institute of Clinical Medicine

Moscow

 

miss.sapog@mail.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России (Пироговский университет)Pirogov Russian National Research Medical University202513112025636776Copyright © Левицкая А.Н., Демидова Т.Ю., Лобанова К.Г., 20252025Левицкая А.Н., Демидова Т.Ю., Лобанова К.Г.Levitskaya A.N., Demidova T.Y., Lobanova K.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/179

Нарушение эффектов инкретиновых гормонов – ведущая причина развития сахарного диабета 2 типа (СД2) и ожирения. В настоящее время наиболее эффективными группами препаратов для лечения как СД2, так и ожирения считаются агонисты рецепторов глюкагоноподобного пептида-1 (семаглутид, лираглутид и др.) и двойные агонисты рецепторов глюкозозависимого инсулинотропного полипептида / глюкагоноподобного пептида-1 (тирзепатид). При этом наиболее эффективным в отношении контроля гликемии и снижения массы тела является тирзепатид, за которым следуют семаглутид и лираглутид.

Impaired effects of incretin hormones are the leading cause of type 2 diabetes mellitus (T2DM) and obesity. Currently, the most effective groups of drugs for the treatment of both T2DM and obesity are glucagon-like peptide-1 receptor agonists (semaglutide, liraglutide, etc.) and dual glucose-dependent insulinotropic polypeptide / glucagon-like peptide-1 receptor agonists (tirzepatide). Tirzepatide is the most effective in terms of glycemic control and weight loss, followed by semaglutide and liraglutide.

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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): A double-blind, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet Lond Engl. 2023;402(10402):613–26. doi: 10.1016/S0140-6736(23)01200-X.Листок-вкладыш – информация для пациента. Тирзетта® 2,5 мг/доза, раствор для подкожного введения. Тирзетта® 5,0 мг/доза, раствор для подкожного введения. Тирзетта® 7,5 мг/доза, раствор для подкожного введения. Тирзетта® 10 мг/доза, раствор для подкожного введения. Тирзетта® 12,5 мг/ доза, раствор для подкожного введения. Тирзетта® 15 мг/доза, раствор для подкожного введения. Соответствует экспертному отчету от 21.01.2025, № 1125 (последовательность 0002).Листок-вкладыш – информация для пациента. Тирзетта® 2,5 мг/доза, раствор для подкожного введения. Тирзетта® 5,0 мг/доза, раствор для подкожного введения. Тирзетта® 7,5 мг/доза, раствор для подкожного введения. Тирзетта® 10 мг/доза, раствор для подкожного введения. Тирзетта® 12,5 мг/ доза, раствор для подкожного введения. Тирзетта® 15 мг/доза, раствор для подкожного введения. Соответствует экспертному отчету от 21.01.2025, № 1125 (последовательность 0002).

The authors declare that there are no conflicts of interest present.