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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">endofocus</journal-id><journal-title-group><journal-title xml:lang="ru">FOCUS Эндокринология</journal-title><trans-title-group xml:lang="en"><trans-title>FOCUS. Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-0177</issn><issn pub-type="epub">2713-0185</issn><publisher><publisher-name>ООО "Издательство "Перо"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.62751/2713-0177-2026-7-2-10</article-id><article-id custom-type="elpub" pub-id-type="custom">endofocus-209</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group></article-categories><title-group><article-title>Пароксизм фибрилляции предсердий как маска тиреотоксикоза у пожилого пациента: особенности диагностики и роль скрытых причин</article-title><trans-title-group xml:lang="en"><trans-title>Atrial fibrillation paroxysm as a mask of thyrotoxicosis in an elderly patient: Diagnostic features and the role of hidden causes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5512-6899</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушанова</surname><given-names>Ф. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Fatima</surname><given-names>O. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ушанова Фатима Омариевна – к.м.н., доцент кафедры эндокринологии </p><p>117513, г. Москва, ул. Островитянова д. 1 </p></bio><bio xml:lang="en"><p>Fatima O. Ushanova – C. Sci. (Med.) </p><p>1 Ostrovityanova St., Moscow, 117997 </p></bio><email xlink:type="simple">fati_2526@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3911-8543</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аракелов</surname><given-names>С. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Arakelov</surname><given-names>S. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аракелов Сергей Эрнестович – д.м.н. проф., главный врач </p><p>Москва </p></bio><bio xml:lang="en"><p>Sergey E. Arakelov – Dr. Sci. (Med.), prof., chief physician</p><p>Moscow </p></bio><email xlink:type="simple">doctorgkv@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-8724-6721</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Омарова</surname><given-names>Марин Мусаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Omarova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Омарова Марин Мусаевна – клинический ординатор </p><p>Москва </p></bio><bio xml:lang="en"><p>Marin M. Omarova – clinical resident</p><p>Moscow </p></bio><email xlink:type="simple">marinomarova@icloud.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая больница имени В.П. Демихова ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.P. Demikhov City Clinical Hospital of the Moscow City Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2026</year></pub-date><volume>7</volume><issue>2</issue><fpage>73</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ушанова Ф.О., Аракелов С.Э., Омарова М.М., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Ушанова Ф.О., Аракелов С.Э., Омарова М.М.</copyright-holder><copyright-holder xml:lang="en">Fatima O.U., Arakelov S.E., Omarova M.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://endofocus.elpub.ru/jour/article/view/209">https://endofocus.elpub.ru/jour/article/view/209</self-uri><abstract><p>Своевременное выявление тиреотоксикоза у пожилых людей зачастую сопряжено со сложностями, так как состояние в большинстве случаев характеризуется малосимптомным течением, а классические симптомы гиперактивации симпатической нервной системы могут быть стертыми или вовсе отсутствовать. В представленном наблюдении описывается клинический случай пациента 68 лет с отягощенным кардиологическим анамнезом, у которого впервые возникший пароксизм фибрилляции предсердий выступил в роли «кардиальной маски» синдрома тиреотоксикоза и отправной точки для дальнейшего диагностического поиска. Несмотря на положительный титр антител к рецепторам тиреотропного гормона, диагноз диффузного токсического зоба вызывал сомнения, в связи с чем пациенту было выполнено дообследование с целью уточнения причины тиреотоксикоза. При проведении сцинтиграфии щитовидной железы был выявлен локальный фокус повышенного захвата радиофармпрепарата в проекции ранее выявленной микрокарциномы. Развитие тяжелого лекарственного гепатита на фоне приема тиамазола сделало невозможной стандартную предоперационную подготовку. Этот случай подчеркивает диагностическую ценность впервые возникшей фибрилляции предсердий у коморбидных пациентов, необходимость онкологической настороженности даже в отношении узлов с признаками функциональной активности, а также важность персонализированного междисциплинарного подхода в сложных клинических ситуациях. </p></abstract><trans-abstract xml:lang="en"><p>Timely detection of thyrotoxicosis in the elderly is often difficult, since the condition in most cases is characterized by a low-symptomatic course, and the classic symptoms of hyperactivation of the sympathetic nervous system may be erased or completely absent. The presented case study describes a clinical case of a 68-year-old patient with a burdened cardiological history, in whom a paroxysm of atrial fibrillation for the first time appeared as a “cardiac mask” of thyrotoxicosis syndrome and a starting point for further diagnostic search. Despite the positive titer of antibodies to thyroid-stimulating hormone receptors, the diagnosis of diffuse toxic goiter caused complications, and therefore the patient underwent further examination to clarify the cause of thyrotoxicosis. Thyroid scintigraphy revealed a local focus of increased radiopharmaceutical uptake in the projection of a previously identified microcarcinoma. The development of severe drug-induced hepatitis while taking thiamazole made standard preoperative preparation impossible. This case highlights the diagnostic value of newly emerging atrial fibrillation in comorbid patients, the need for oncological vigilance even in relation to nodes with signs of functional activity, as well as the importance of a personalized interdisciplinary approach in complex clinical situations. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>тиреотоксикоз</kwd><kwd>папиллярный рак щитовидной железы</kwd><kwd>функционально активный рак щитовидной железы</kwd><kwd>функциональная автономия</kwd><kwd>лекарственный гепатит</kwd><kwd>радиойодтерапия</kwd><kwd>синдром Марин – Ленхарта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>thyrotoxicosis</kwd><kwd>papillary thyroid cancer</kwd><kwd>functioning thyroid cancer</kwd><kwd>functional autonomy</kwd><kwd>drug-induced hepatitis</kwd><kwd>radioiodine therapy</kwd><kwd>Marine – Lenhart syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мельниченко Г.А., Ларина И.И. 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