endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2024-5-4-17endofocus-69Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWАдренокортикальный рак: прогноз, лечение и иммунное микроокружениеAdrenocortical cancer: Prognosis, treatment and immune microenvironmenthttps://orcid.org/0000-0002-8136-0117ПачуашвилиН. В.PachuashviliN. V.

Пачуашвили Нано Владимеровна – к.м.н., младший научный сотрудник Лаборатории эндокринной биофотоники отдела фундаментальной патоморфологии ГНЦ ФГБУ «НМИЦ эндокринологии» Минздрава России

Москва

Nano V. Pachuashvili – Can. Sci. (Med.), Junior Research Assistant at Fundamental Pathomorphology of Endocrinology Research Centre

Moscow

npachuashvili@bk.ruhttps://orcid.org/0000-0002-2611-9320ПорубаеваЭ. Э.PorubaevaE. E.

Порубаева Эрика Эдуардовна – младший научный сотрудник Лаборатории эндокринной биофотоники отдела фундаментальной патоморфологии ГНЦ ФГБУ «НМИЦ эндокринологии» Минздрава России

Москва

Erika E. Porubayeva – Junior Research Assistant at Fundamental Pathomorphology of Endocrinology Research Centre

Moscow

porubaeva.erika@bk.ruhttps://orcid.org/0000-0001-6891-0009УрусоваЛ. С.UrusovaL. S.

Урусова Лилия Сергеевна – д.м.н., заведующая отделом фундаментальной патоморфологии ГНЦ ФГБУ «НМИЦ эндокринологии» Минздрава России

Москва

Liliya S. Urusova – D. Sci. (Med.), Head of the Department of Fundamental Pathomorphology of Endocrinology Research Centre

Moscow

liselivanova89@yandex.ruГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)Endocrinology Research Centre; I.M. Sechenov First Moscow State Medical University, Ministry of Healthcare of RussiaГНЦ РФ ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава России; ФГАОУ ВО «Московский государственный университет имени М. В. Ломоносова»Endocrinology Research Centre; M.V. Lomonosov Moscow State University202425122024543539Copyright © Пачуашвили Н.В., Порубаева Э.Э., Урусова Л.С., 20252025Пачуашвили Н.В., Порубаева Э.Э., Урусова Л.С.Pachuashvili N.V., Porubaeva E.E., Urusova L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/69

Адренокортикальный рак (АКР) – редкая злокачественная опухоль из клеток коры надпочечника с частотой встречаемости 0,7–2 случая на 1 млн населения в год. Из-за трудностей диагностики АКР часто обнаруживается уже на стадии метастазирования, что ограничивает возможности хирургического вмешательства и предполагает крайне неблагоприятный прогноз. Состав микроокружения опухоли имеет решающее значение для разработки стратегий иммунотерапии рака. Одним из компонентов микроокружения опухоли являются иммунные клетки, наличие которых нередко ассоциируется с лучшим прогнозом для пациентов при многих злокачественных новообразованиях. Цель данного обзора – описать современные возможности прогнозирования течения и лечения пациентов с АКР, а также сфокусироваться на последних опубликованных данных, касающихся иммунного микроокружения опухоли, чтобы дать некоторые представления о перспективах его использования для персонализированного ведения пациентов.

Adrenocortical cancer (ACС) is a rare malignant endocrine tumor from cells of the adrenal cortex with an incidence of 0.7–2 cases per 1 million population per year. Due to difficulties in diagnosis, ACС is detected already at the stage of metastasis, which limits the possibilities of surgical intervention and implies an unfavorable prognosis. The composition of the tumor microenvironment is crucial for the development of strategies for immunotherapeutic treatment of cancer. One component of the tumor microenvironment is immune cells, the presence of which is often associated with a better prognosis for patients. The purpose of this review is to describe the current possibilities for predicting the course and treatment of patients with ACC, as well as to focus on the latest published data on the immune microenvironment of the tumor in order to give some ideas about the prospects for its use for personalized patient management.

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The authors declare that there are no conflicts of interest present.