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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">endofocus</journal-id><journal-title-group><journal-title xml:lang="ru">FOCUS Эндокринология</journal-title><trans-title-group xml:lang="en"><trans-title>FOCUS. Endocrinology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2713-0177</issn><issn pub-type="epub">2713-0185</issn><publisher><publisher-name>ООО "Издательство "Перо"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.62751/2713-0177-2024-5-1-05</article-id><article-id custom-type="elpub" pub-id-type="custom">endofocus-86</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Овариальный резерв у пациенток с  ожирением: куда пропадают яйцеклетки?</article-title><trans-title-group xml:lang="en"><trans-title>Ovarian reserve in obese patients: where do the eggs disappear?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2462-3320</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Азизова</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Azizova</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Азизова Каринэ Валентиновна  –  аспирант кафедры терапии факультетской с  курсом эндокринологии и  кардиологии с клиникой имени академика Г. Ф. Ланга</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Karine V.   Azizova  –   postgraduate student of the Faculty Therapy Department with a  course in Endocrinology and Cardiology with the Clinic named after Academician  G. F. Lang</p><p>Saint Petersburg</p></bio><email xlink:type="simple">rika94@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8249-6075</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дора</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dora</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дора Светлана Владимировна  –    д.  м.  н., доцент кафедры терапии факультетской с   курсом эндокринологии и  кардиологии с   клиникой имени академика Г. Ф. Ланга</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Svetlana V.  Dora  –    Doc. Sci. (Med.), Associate Professor of the Department of Faculty Therapy  with a   course in Endocrinology and Cardiology with the Clinic named after Academician   G.  F.  Lang</p><p>Saint Petersburg</p></bio><email xlink:type="simple">doras2001@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7755-7275</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халимов</surname><given-names>Ю. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalimov</surname><given-names>Yu. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Халимов Юрий Шавкатович  –   д.  м.  н., профессор, заведующий кафедрой терапии факультетской с  курсом эндокринологии и кардиологии с клиникой имени академика Г. Ф. Ланга</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Yuri Sh. Khalimov   –  Doc. Sci. (Med.), Professor, Head of the Faculty Department of Therapy with a  course in Endocrinology and Cardiology with the Clinic named after Academician  G. F.  Lang</p><p>Saint Petersburg</p></bio><email xlink:type="simple">yushkha@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5189-9365</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волкова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Volkova</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Волкова Анна Ральфовна  –  д.  м.  н., профессор кафедры терапии факультетской с курсом эндокринологии и  кардиологии с клиникой имени академика Г. Ф. Ланга</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Anna R.  Volkova –   Doc. Sci. (Med.), Professor of the Department of Faculty Therapy with a course in Endocrinology and Cardiology with the Clinic named after Academician  G. F. Lang</p><p>Saint Petersburg</p></bio><email xlink:type="simple">volkovaa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чебоксарова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cheboksarova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чебоксарова Татьяна Алексеевна  –    студентка 6 курса</p><p>197022, г. Санкт- Петербург, ул. Льва Толстого, д. 6–8</p></bio><bio xml:lang="en"><p>Tatyana A.  Cheboksarova  –  student</p><p>Saint Petersburg</p></bio><email xlink:type="simple">sturovatanya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>I. P. Pavlov First Saint-Petersburg State medical university</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>07</day><month>05</month><year>2024</year></pub-date><volume>5</volume><issue>1</issue><fpage>34</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Азизова К.В., Дора С.В., Халимов Ю.Ш., Волкова А.Р., Чебоксарова Т.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Азизова К.В., Дора С.В., Халимов Ю.Ш., Волкова А.Р., Чебоксарова Т.А.</copyright-holder><copyright-holder xml:lang="en">Azizova K.V., Dora S.V., Khalimov Y.S., Volkova A.R., Cheboksarova T.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://endofocus.elpub.ru/jour/article/view/86">https://endofocus.elpub.ru/jour/article/view/86</self-uri><abstract><p>В настоящее время активно обсуждается проблема ожирения и ее влияние на различные аспекты здоровья человека. Широко известна роль ожирения в развитии метаболического синдрома. В рамках изучения пандемии ожирения современным медицинским сообществом проводится исследовательская работа в области репродуктивного здоровья.</p><p>У женщин его показателями считаются маркеры овариального резерва, главным из которых является уровень антимюллерова гормона (АМГ). Известно, что с возрастом количество АМГ и антральных фолликулов в организме женщины снижается. Однако в современной литературе есть данные, указывающие на снижение показателей овариального резерва в условиях повышения массы тела. Увеличение веса сопровождается дисбалансом адипоцитокинов – биологически активных веществ, вырабатываемых преимущественно жировой тканью и другими тканями организма, влияющих на метаболические процессы. Следует полагать, что глубокое изучение взаимосвязи снижения репродуктивного потенциала и ожирения, своевременная профилактика метаболических нарушений позволят улучшить показатели фертильности.</p></abstract><trans-abstract xml:lang="en"><p>Currently, the issue of obesity and its impact on various aspects of human health is actively being discussed. The role of obesity in the development of metabolic syndrome is well known. Within the study of the obesity pandemic, the modern medical community is conducting research in the field of reproductive health. In women, markers of ovarian reserve are considered, with the main one being the level of anti-Mullerian hormone (AMH). It is known that with age, the number of AMH and antral follicles in a woman's body decreases. However, there is data in the modern literature indicating a decrease in ovarian reserve parameters in conditions of weight gain. Weight gain is accompanied by a imbalance of adipokines - biologically active substances produced mainly by adipose tissue and other tissues of the body that affect metabolic processes. It can be assumed that a deep study of the relationship between decreased reproductive potential and obesity, timely prevention of metabolic disorders will improve fertility indicators.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>овариальный резерв</kwd><kwd>ожирение</kwd><kwd>адипоцитокины</kwd><kwd>антимюллеров гормон</kwd><kwd>антральные фолликулы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ovarian reserve</kwd><kwd>obesity</kwd><kwd>adipocytokines</kwd><kwd>anti-Mullerian hormone</kwd><kwd>antral follicles</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Всемирная организация здравоохранения. Бесплодие. 2020. [Электронный ресурс]. 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