endofocusFOCUS ЭндокринологияFOCUS. Endocrinology2713-01772713-0185ООО "Издательство "Перо"10.62751/2713-0177-2024-5-3-02endofocus-88Research ArticleОРИГИНАЛЬНОЕ ИССЛЕДОВАНИЕORIGINAL RESEARCHВлияние COVID-19 на экзокринную и эндокринную функции поджелудочной железы: клинико-патогенетические особенности и ассоциация с тяжестью течения инфекцииUnderstanding the influence of COVID-19 on pancreatic exocrine and endocrine function: сlinical and pathogenetic insights and their correlation with infection severityhttps://orcid.org/0000-0002-8325-5927ЖароваМ. Е.ZharovaM. E.

Жарова Мария Евгеньевна, к.м.н., старший лаборант кафедры гастроэнтерологии ФДПО ИНОПР

г. Москва

Maria E. Zharova, PhD, Senior laboratory assistant

Moscow

zharowa.mariya@yandex.ruhttps://orcid.org/0000-0002-5231-711XНиконовЕ. Л.NikonovE. L.

Никонов Евгений Леонидович, д.м.н., профессор, заведующий кафедрой гастроэнтерологии ФДПО ИНОПР

г. Москва

Evgeny L. Nikonov, MD, Professor

Moscow

drnikonov@mail.ruhttps://orcid.org/0000-0001-6691-8306ИваниковИ. О.IvanikovI. O.

Иваников Игорь Олегович, д.м.н., профессор кафедры гастроэнтерологии ФДПО ИНОПР; Научный руководитель по гастроэнтерологии

г. Москва

Igor O. Ivanikov, MD, Professor of the Department of Gastroenterology; Scientific Director of Gastroenterology

Moscow

ivanikov51@mail.ruhttps://orcid.org/0000-0001-5335-7933ГригорьеваЮ. В.GrigoryevaYu. V.

Григорьева Юлия Васильевна, к.м.н., ассистент кафедры гастроэнтерологии ФДПО ИНОПР; заведующая отделением гастроэнтерологии

г. Москва

Yulia V. Grigorieva, PhD, Assistant Professor of Gastroenterology at the Department of Gastroenterology; Head of the Gastroenterology Department

Moscow

iulka707@mail.ruФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава РоссииPirogov Russian National Research Medical UniversityФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России; ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента Российской ФедерацииPirogov Russian National Research Medical University; Central Clinical Hospital of Russian Federation Presidential Administration202407112024531220Copyright © Жарова М.Е., Никонов Е.Л., Иваников И.О., Григорьева Ю.В., 20242024Жарова М.Е., Никонов Е.Л., Иваников И.О., Григорьева Ю.В.Zharova M.E., Nikonov E.L., Ivanikov I.O., Grigoryeva Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://endofocus.elpub.ru/jour/article/view/88Цель

Цель. Изучить клинико-патогенетические особенности поражения поджелудочной железы у пациентов с COVID-19.

Материал и методы

Материал и методы. Проанализированы 200 историй болезни пациентов с COVID-19, госпитализированных в перепрофилированное отделение гастроэнтерологии для лечения больных с COVID-19 ФГБУ «Центральная клиническая больница с поликлиникой» УДП Российской Федерации в период с марта 2020 по июль 2021 года.

Результаты

Результаты. Из сопутствующих заболеваний сахарный диабет 2 типа и нарушение толерантности к глюкозе (СД2/НТГ) встречались у 39 (19,5%), хронический панкреатит – у 10 (5%) человек. Наличие СД2/НТГ в анамнезе было ассоциировано с более длительным пребыванием пациентов в стационаре (p=0,0024). У 11,5% пациентов было отмечено повышение ферментов поджелудочной железы, которое ассоциировалось с тяжестью течения COVID-19 (p <0,0001) и с более длительной госпитализацией (p=0,0002). Статистически значимая связь была обнаружена между возрастом и риском повышения ферментов поджелудочной железы (p=0,0011).

Заключение

Заключение. Поражение поджелудочной железы у пациентов с COVID-19 может быть серьезной клинической проблемой, ухудшающей клинические исходы. Результаты исследования подчеркивают важность мониторинга ферментов поджелудочной железы и гликемического профиля в протоколах обследования пациентов с COVID-19 для ранней диагностики и адекватного лечения осложнений.

The aim

The aim. This study aims to investigate the clinical and pathogenetic features of pancreatic involvement in patients diagnosed with COVID-19. Material and methods. We conducted an analysis of two hundred medical records belonging to patients hospitalized with COVID-19 at the gastroenterology department of the Central Clinical Hospital of Russian Federation Presidential Administration, from March 2020 to July 2021.

Results

Results. Among the comorbidities observed, type 2 diabetes mellitus and glucose intolerance (T2DM/GI) were present in 39 (19.5%) patients, while chronic pancreatitis was evident in 10 (5%) patients. Notably, a history of T2DM/GI correlated with prolonged hospital stays (p=0.0024). Elevated pancreatic enzyme levels were detected in 11.5% of patients, showing a significant association with the COVID-19 severity (p=0.0001) and prolonged hospitalization (p=0.0002). Furthermore, a statistically significant correlation was found between age and the risk of elevated pancreatic enzyme levels (p=0.0011).

Conclusion

Conclusion. The involvement of the pancreas in COVID-19 patients poses a significant clinical challenge, exacerbating overall clinical outcomes. These findings underscore the critical importance of monitoring pancreatic enzymes and glycemic profiles within the evaluation protocols of COVID-19 patients to facilitate early diagnosis and ensure prompt treatment of complications.

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The authors declare that there are no conflicts of interest present.