Long-term efficacy of metformin and primary prevention of complications of type 2 diabetes mellitus: Results from 42-year UKPDS follow-up
https://doi.org/10.62751/2713-0177-2024-5-4-16
Abstract
Metformin, long considered a mainstay of treatment for type 2 diabetes mellitus (T2DM), has recently received new evidence of its effectiveness. Results from a 24-year follow-up of patients who completed the 20-year UKPDS study have demonstrated a significant benefit of early metformin administration in preventing diabetes complications. The extension study included 1489 patients with a mean age of 70.9 years. After 42 years of follow-up after randomization in the UKPDS, the metformin group retained a numerical advantage in preventing T2DM outcomes compared with the sulfonylurea/insulin group: any outcome related to DM (18% vs. 10%), death related to DM (25% vs. 16%), death from any cause (20% vs. 10%), myocardial infarction (31% vs. 17%). These results were significantly different from the diet therapy group (p <0.05). Thus, metformin was found to have a primary preventive effect on the outcomes of T2DM, which persists throughout almost the entire life of the patient with this disease.
About the Authors
F. O. Ushanova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Fatima O. Ushanova – C. Sci. (Med.)
Moscow
T. Ya. Izmailova
Russian University of Medicine of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Tamara Y. Izmailova – student
Moscow
T. L. Bogacheva
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Tatyana L. Bogacheva – assistant
Moscow
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Review
For citations:
Ushanova F.O., Izmailova T.Ya., Bogacheva T.L. Long-term efficacy of metformin and primary prevention of complications of type 2 diabetes mellitus: Results from 42-year UKPDS follow-up. FOCUS. Endocrinology. 2024;5(4):28-34. (In Russ.) https://doi.org/10.62751/2713-0177-2024-5-4-16
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