The problem of hypothyroidism today: Current challenges and solutions
https://doi.org/10.62751/2713-0177-2025-6-3-08
Abstract
Hypothyroidism is a clinical syndrome resulting from decreased thyroid function, manifested by decreased thyroid hormone levels in the blood. The incidence of hypothyroidism varies by gender and age. This article examines the key causes of primary and secondary hypothyroidism. The main factor causing primary hypothyroidism is autoimmune thyroiditis, which can occur in isolation or in combination with other autoimmune pathologies. The severity of clinical manifestations depends on the degree of thyroid hormone deficiency. The symptoms of hypothyroidism are described in detail, with an emphasis on pathological changes in the cardiovascular system. Hypothyroidism is most common in elderly patients and the elderly, who are characterized by a vague clinical picture. Special attention is given to the difficulties of diagnosing hypothyroidism, which sometimes masquerades as symptoms of other diseases. Confirmation of the diagnosis requires a range of laboratory and instrumental studies. Hypothyroidism, regardless of its cause, is treated with sodium levothyroxine (L-T4) replacement therapy. Recommendations for optimizing treatment approaches for thyroid insufficiency are provided.
About the Authors
E. V. Biryukova
Russian University of Medicine
Russian Federation
Russian Federation
Elena V. Biryukova – D. Sci (Med.), professor of the Department of endocrinology
Moscow
N. M. Platonova
National Medical Research Center for Endocrinology
Russian Federation
Russian Federation
Nadezhda M. Platonova – D. Sci (Med.), Head of the Department of therapeutic endocrinology
Moscow
M. V. Shinkin
A.S. Loginov Moscow Clinical Research Center
Russian Federation
Russian Federation
Mikhail V. Shinkin – Researcher at the Department of endocrine and metabolic diseases, endocrinologist
Moscow
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Review
For citations:
Biryukova E.V., Platonova N.M., Shinkin M.V. The problem of hypothyroidism today: Current challenges and solutions. FOCUS. Endocrinology. 2025;6(3):59-66. (In Russ.) https://doi.org/10.62751/2713-0177-2025-6-3-08
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