Diabetes-associated factors in hospitalized COVID-19 patients with concomitant type 2 diabetes mellitus: focus on mean in-hospital glycemic values
https://doi.org/10.62751/2713-0177-2024-5-2-13
Abstract
Aim of the study: to evaluate the significance of mean glycemic values during hospitalization as a potentially important diabetes-associated risk factor of unfavorable outcomes in inpatients with COVID-19 and type 2 diabetes mellitus (T2DM).
Materials and methods. 139 patients with COVID-19 were observed in the hospital, 42 of them had concomitant type 2 diabetes mellitus (DM2). In patients with COVID-19 and type 2 diabetes, the relationship between mean glycemic values during hospitalization and adverse outcomes (death and/or transfer of the patient to the intensive care unit (ICU)) was assessed. The average number of tests to assess glycemia in the hospital was 38.4 ± 15.68 per patient.
Results and discussion. According to correlation analysis data, an increase in mean in-hospital glycemia correlated with the severity of lung damage by computed tomography (R = 0.54, p = 0.002), the need for respiratory support by SMRT-CO score (R = 0.29, p = 0.070) and hypercoagulation by the international normalized ratio (R= –0.42, p=0.008). According to regression analysis, predictors of unfavorable outcomes included mean in-hospital glycemia (OR 1.4 [0.93; 2.12], p=0.073) and the percentage of tests with hypoglycemia in the hospital (OR 2.09 [0.89; 5 .40], p=0.016) as well as a history of diabetes (OR 5.5 [0.95, 31.60], p=0.029).
Conclusion. Impaired glycemic control during the whole hospitalization period negatively affects disease severity and the risk of adverse outcomes in patients with COVID-19 and type 2 diabetes.
About the Authors
D. V. Belkina
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Darya V. Belkina– Assistant of the Department of Endocrinology and Internal Diseases
Nizhny Novgorod
T. A. Nekrasova
Privolzhsky Research Medical University
Tatyana A. Nekrasova– Doc. Sci. (Med.), Associate Professor, Professor of the Department of Endocrinology and Internal Diseases
Nizhny Novgorod
L. G. Strongin
Privolzhsky Research Medical University
Leonid G. Strongin – Doc. Sci. (Med.), Professor; Professor of the Department of Endocrinology and Internal Medicine
Nizhny Novgorod
E. M. Durygina
Privolzhsky Research Medical University
Elena M. Durygina – Can. Sci. (Med.), Associate Professor of the Department of Internal Medicine and Cardiology
Nizhny Novgorod
M. Yu. Rodina
Privolzhsky Research Medical University
Marina Yu. Rodina – Assistant of the Department of Faculty and Outpatient Therapy
Nizhny Novgorod
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Review
For citations:
Belkina D.V., Nekrasova T.A., Strongin L.G., Durygina E.M., Rodina M.Yu. Diabetes-associated factors in hospitalized COVID-19 patients with concomitant type 2 diabetes mellitus: focus on mean in-hospital glycemic values. FOCUS. Endocrinology. 2024;5(2):20-24. (In Russ.) https://doi.org/10.62751/2713-0177-2024-5-2-13
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