Semaglutide in type 2 diabetes management: review of current evidence from concept to date

Clinical guidelines increasingly emphasize the importance of multifactorial treatment of type 2 diabetes (DM2), including both glycemic control and body weight control, comprehensive management of classical cardiological risk factors, as well as the use of drugs with proven cardionephroprotective effects to reduce the risk of long-term complications. The development of semaglutide, a long—acting and highly homologous receptor agonist of glucagon-like peptide-1 (arGPP-1) based on a widely recognized representative of the liraglutide class, was an important milestone in expanding the possibilities of disease management, and the successes achieved in the clinical research program of the drug contributed to the formation of the above aspects of the recommendations.

The clinical efficacy of semaglutide was evaluated in the framework of the SUSTAIN clinical research program for more than 10,000 patients with DM2. The program includes 6 major global studies of Phase IIIa (SUSTAIN 1-6) and 5 studies of phase IIIb (SUSTAIN 7-11), as well as a number of other studies and analyses.

The development of a domestic reproduced drug containing semaglutide will increase the availability of semaglutide preparations in the Russian Federation, as well as significantly more effectively control the level of glycemia in patients with DM2. This review presents the results of the efficacy and safety of semaglutide, including the Russian bioequivalent drug semaglutide.

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