The influence of cardiovascular autonomic neuropathy on blood pressure profile in patients with a combination of diabetes mellitus type 2 and arterial hypertension
https://doi.org/10.62751/2713-0177-2025-6-4-01
Abstract
The aim of the study: to study the influence of cardiovascular autonomic neuropathy (CAN) on the blood pressure (BP) profile in patients with a combination of diabetes mellitus type 2 and hypertension.
Material and methods. 36 patients with a combination of diabetes mellitus type 2 and hypertension were examined. Ambulatory BP monitoring (ABPM), 5 standard cardiovascular tests (CVT) according to Ewing, and analysis of heart rate variability were performed. Based on the results of the CVT, the patients were divided into 2 groups: CAN (+) and CAN (-). Glycated hemoglobin and the time in the target range (TIR) were used to analyze glycemic control.
Results. CAN (+) group had higher level of glycated hemoglobin and decreased TIR. Statistically significant differences in heart rate variability were revealed: SDNN, total spectrum power (TP) and “cloud” area of scatterplot were lower in the CAN (+) group. Patients with CAN had higher mean values and systolic pressure (SP) load during the day and mean values and SP and diastolic pressure (DP) load at night, increased BP variability during the day and at night and an increase in the pulse pressure. The CAN (+) group was dominated by night-peakers for SP: 71 vs. 16% (p=0.002) and non-dippers for DP: 47 vs. 16% (p=0.05).
Conclusion. The study allows us to conclude about the relationship of the cardiovascular relationship of CAN with the worst indicators of glycemic control. The presence of autonomic dysfunction is associated with the absence of a normal decrease or increase BP at night, higher mean values of SP, indicators of BP variability, increased pulse pressure.
About the Authors
A. V. Bushueva
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Alexandra V. Bushueva – C. Sci (Med), Associate Professor of the Department of endocrinology and internal diseases
Nizhny Novgorod
D. I. Korneeva
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Diana I. Korneeva – student at the Faculty of general medicine
Nizhny Novgorod
L. G. Strongin
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Leonid G. Strongin – D. Sci. (Med.), Professor, Department of endocrinology and internal medicine
Researcher ID: ABD-1913-2020
Scopus Author ID: 6506336513
Nizhny Novgorod
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Review
For citations:
Bushueva A.V., Korneeva D.I., Strongin L.G. The influence of cardiovascular autonomic neuropathy on blood pressure profile in patients with a combination of diabetes mellitus type 2 and arterial hypertension. FOCUS. Endocrinology. 2025;6(4):6-11. (In Russ.) https://doi.org/10.62751/2713-0177-2025-6-4-01
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