Juvenile fibroadenoma of the breast in a 7-year-old girl with precocious puberty
https://doi.org/10.62751/2713-0177-2025-6-4-11
Abstract
We present the first reported case of a juvenile fibroadenoma (FA) in a seven-year-old girl with gonadotropin-dependent precocious puberty (PP). The girl was admitted to the Endocrinology Research Centre with accelerated growth and breast asymmetry. Examination revealed central PP and a solid mass in the left breast. Surgical excision of the mass was performed at the N.N. Blokhin National Medical Research Center of Oncology, juvenile FA was confirmed. Postoperative ultrasound showed residual fibromatous tissue, oncologic follow-up was recommended. At the age of 7.5 years, therapy with gonadotropin-releasing hormone analogs was initiated, resulting in regression of the tumor foci over the course of 20 months. The clinical data suggest a potential association between the FA and PP: manifestation at the onset of puberty and regression in response to a decrease in sex hormone levels. FA may therefore represent a possible complication of PP. This hypothesis requires further investigation.
Supporting agencies: The work was conducted within the framework of state contract topic 123021000045-4 “Genetic personalization of rare variants of growth retardation and sexual development delay in children”.
About the Authors
A. E. Shapovalova
Endocrinology Research Centre
Russian Federation
Russian Federation
Anna E. Shapovalova – resident
Moscow
N. V. Makazan
Endocrinology Research Centre
Russian Federation
Russian Federation
Nadezhda V. Makazan – C. Sci. (Med.), researcher
Moscow
I. S. Chugunov
Endocrinology Research Centre
Russian Federation
Russian Federation
Nadezhda V. Makazan – C. Sci. (Med.), researcher
Moscow
O. B. Bezlepkina
Endocrinology Research Centre
Russian Federation
Russian Federation
Olga B. Bezlepkina – D. Sci. (Med.), Professor, Director of Institute of Pediatric Endocrinology
Moscow
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For citations:
Shapovalova A.E., Makazan N.V., Chugunov I.S., Bezlepkina O.B. Juvenile fibroadenoma of the breast in a 7-year-old girl with precocious puberty. FOCUS. Endocrinology. 2025;6(4):94-99. (In Russ.) https://doi.org/10.62751/2713-0177-2025-6-4-11
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