Sertoli-Leydig cell tumor in a patient with hyperandrogenism: New approaches to diagnosis
K. D. Musevich,
N. V. Vorokhobina,
Z. R. Shafigullina,
V. L. Baranov,
T. V. Eremenko,
M. A. Khassaan,
D. V. Bogaevskaia,
Yu. V. Kovalyova https://doi.org/10.62751/2713-0177-2026-7-1-12
Abstract
The article presents a clinical case of a 55-year-old woman who was diagnosed with hyperplasia of the medial pedicle of the left adrenal gland and the formation of the left ovary against the background of pronounced manifestations of hyperandrogenism syndrome: androgen-dependent alopecia, hirsutism, arterial hypertension, fasting and postprandial hyperglycemia. Hyperandrogenism was confirmed by laboratory tests, the hormonal activity of the left adrenal hyperplasia was excluded. Using gas chromatography-mass spectrometry of daily urine and selective blood sampling from the ovarian veins with an assessment of the concentration of androstenedione and testosterone, the ovarian origin of hyperandrogenism syndrome was proved. The patient underwent laparoscopic extirpation of the uterus and appendages, followed by regression of symptoms. The normalization of hormones was biochemically confirmed after 3 months. The clinical case demonstrates the high sensitivity and specificity of gas chromatography-mass spectrometry, highlighting the importance of this method for the differential diagnosis of adrenal and gonadal diseases.
Keywords
hyperandrogenism syndrome,
Sertoli-Leydig cell tumor,
urine steroid profile,
gas chromatography-mass spectrometry
Supporting agencies: None
About the Authors
K. D. Musevich
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Ksenia D. Musevich
195253; Marshal Tukhachevsky St., 23, building 1, apt. 570; Saint Petersburg
N. V. Vorokhobina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Natalia V. Vorokhobina, Dr. Sci. (Med.), professor
Saint Petersburg
Z. R. Shafigullina
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Zulfiya R. Shafigullina, Cand. Sci. (Med.)
Saint Petersburg
V. L. Baranov
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Vitalii L. Baranov, Dr. Sci. (Med.), professor
Saint Petersburg
T. V. Eremenko
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Tatyana V. Eremenko, Cand. Sci. (Med.). associate professor
Saint Petersburg
M. A. Khassaan
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Marina A. Khassaan
Saint Petersburg
D. V. Bogaevskaia
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Diana V. Bogaevskaia
Saint Petersburg
Yu. V. Kovalyova
North-Western State Medical University named after I.I. Mechnikov
Russian Federation
Russian Federation
Yuliya V. Kovalyova, Cand. Sci. (Med.), associate professor
Saint Petersburg
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For citations:
Musevich K.D., Vorokhobina N.V., Shafigullina Z.R., Baranov V.L., Eremenko T.V., Khassaan M.A., Bogaevskaia D.V., Kovalyova Yu.V. Sertoli-Leydig cell tumor in a patient with hyperandrogenism: New approaches to diagnosis. FOCUS. Endocrinology. 2026;7(1):95-100. (In Russ.) https://doi.org/10.62751/2713-0177-2026-7-1-12
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